Pair Name	Epigallocatechin gallate, Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Immunogenic cell death
Gene Regulation	Down-regulation	Expression	ABCB1	hsa5243
In Vitro Model	MCF-7	Invasive breast carcinoma of no special type	Homo sapiens (Human)	CVCL_0031
	NCI-ADR-RES	High grade ovarian serous adenocarcinoma	Homo sapiens (Human)	CVCL_1452
In Vivo Model	About 1.0×10⁶ MCF-7/ADR cells were slowly injected into the subcutaneous region of male nude mice.
Result	PEI-DOX/EGCG/FA can inhibit the expression of P-gp and reverse the MDR in tumor cells. It also shows the ability of remove oxygen free radicals effectively to prevent the cardiotoxicity of DOX.

Pair Name	Epigallocatechin gallate, Doxorubicin
Disease Info	[ICD-11: 2B51]	Osteosarcoma		Investigative
Biological Phenomena	Induction-->Autophagy
Gene Regulation	Down-regulation	Activity	DLL3	hsa10683
	Down-regulation	Activity	NOTCH3	hsa4854
	Down-regulation	Expression	SOX2-OT	KEGG ID N.A.
In Vitro Model	U2OS	Osteosarcoma	Homo sapiens (Human)	CVCL_0042
	SaOS-2	Osteosarcoma	Homo sapiens (Human)	CVCL_0548
In Vivo Model	1×10⁵ indicated cells were inoculated subcutaneously into the inguinal folds of NOD/SCID mice.
Result	SOX2OT variant 7 contributes to the synergistic interaction between EGCG and Doxorubicin to kill osteosarcoma via autophagy and stemness inhibition

Pair Name	Epigallocatechin gallate, Doxorubicin
Disease Info	[ICD-11: 2B66.Z]	Oral cancer		Investigative
Biological Phenomena	Induction-->Oxidative Stress
Gene Regulation	Up-regulation	Expression	ROS1	hsa6098
In Vitro Model	KB-A1	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_1D82
Result	These results demonstrate that the reversal effect of TP and EGCG on MDR acts, at least in part, regulating the doxorubicin induced intracellular concentration of ROS.